HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 66743788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 60097591 | HCID 60097591 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66743788 | HCID 66743788 | 50.2% |
Reaction Steps
To a solution of 2-amino-5-(pyridin-4-yl)thiophene-3-carboxylic acid (2.20 g, 10 mmol), ammonium chloride (1.09 g, 20 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.30 g, 30 mmol) and 1-hydroxybenzotriazole (1800 mg, 12 mmol) in DMF (100 mL) was added triethylamine (3.0 g, 30 mmol) at room temperature. The reaction mixture was stirred overnight at room temperature. After removal of the solvent, the residue was purified by column chromatography on silica gel (MeOH: DCM=1:19) to give the title compound (1100 mg, 50%) as a brown solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691828B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-3a39cee2396f4b3cb991e3d4bd1ff505 |
| Source note | uspto-grants-2014_04 |