Trifluoroacetic acid → HCID 66742948, compound

Participants

Reaction Steps

A mixture of tert-butyl 4′-oxo-6′-(pyridin-4-yl)-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-thieno[3,2-d]pyrimidine]-1-carboxylate (0.154 g, 0.385 mmol) and trifluoroacetic acid (3.0 mL) was stirred for 1 h at room temperature. The mixture was poured into sat. aqueous sodium hydrogen carbonate (100 mL), ethyl acetate (70 mL) and tetrahydrofuran (30 mL). After shaking well, the yellow precipitate was collected by filtration. This solid was suspended in ethyl acetate-dichloromethane (1:2, 10 mL) and the mixture was heated to 60° C. After 10 min, the precipitate was collected by filtration to afford the title compound (0.107 mg, 93%) as a yellow solid:

Provenance & Evidence