p-Toluenesulfonic acid → HCID 66743595, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-amino-5-(pyridin-4-yl)thiophene-2-carboxamide (0.050 g, 0.23 mmol) in acetic acid (3 mL) were added tetrahydro-4H-thiopyran-4-one 1,1-dioxide (0.068 g, 0.46 mmol) and p-toluenesulfonic acid (0.0040 g, 0.023 mmol). The mixture was heated at 80° C. overnight. Then, the solvent was removed and the obtained residue was taken up in methanol (20 mL). Solid NaHCO3 (1.5 g) was added, and the mixture was stirred for 10 min. The cloudy suspension was filtered and the collected solids were washed with methanol (20 mL) followed by water (30 mL) to give the title compound (0.0195 g, 24%) as a yellow solid:

Provenance & Evidence