反应详情

温度

100 °C

To a stirred solution of phenyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate (0.500 g, 2.50 mmol) in acetone (20 mL) was added indium(III) trifluoromethanesulfonate (0.014 g, 0.025 mmol). The reaction was heated at 100° C. for 20 min. Then, the reaction was allowed to cool to room temperature overnight. The mixture was then concentrated, and the obtained residue was chromatographed (silica gel, hexanes to 40:60 hexanes/ethyl acetate) to give the title compound (0.322 g, 58%) as a white solid:

1. temperatureto cool to room temperature overnight
2. concentrationThe mixture was then concentrated
3. customthe obtained residue was chromatographed (silica gel, hexanes to 40:60 hexanes/ethyl acetate)