p-Toluenesulfonic acid → HCID 66744039, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-5-bromo-N-(4-methoxybenzyl)thiophene-2-carboxamide (160 mg, 0.47 mmol), MgSO4 (60 mg), 2,2-dimethoxypropane (0.5 mL), PTSA (8.6 mg, 0.050 mmol) and DMA (0.5 mL) was stirred at 120° C. for 1 h by using microwave reactor. Then, the mixture was poured into saturated aqueous NaHCO3. The organic materials were extracted with AcOEt. The combined extracts were washed with water and brine, and then dried over Na2SO4. After removal of the solvent at reduced pressure, the residue was purified by column chromatography (silica gel, 90:10 hexane/EtOAc to 40:60 hexane/EtOAc) to give the title compound (112 mg, 62%) as a pale brown solid:

Provenance & Evidence