2,2-Dimethoxypropane → HCID 66743494, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-3-[(2-(morpholin-4-yl)-2-oxoethyl)amino]thiophene-2-carboxamide (120 mg, 0.345 mmol), CSA (10 mg), 2,2-dimethoxypropane (1.0 mL) and DMA (1 mL) was stirred at 80° C. for 0.5 h. Then, water and saturated aqueous NaHCO3 were added to quench the reaction. The precipitate was collected by filtration to afford the title compound (66 mg) as a pale brown solid. From the filtrate, the organic layer was collected, washed with water and brine, dried over Na2SO4 and filtered. The filtrate was concentrated under reduced pressure to afford the title compound (50 mg) as a pale brown solid. Total yield of the title compound (66+50 mg) was 87%:

Provenance & Evidence