HCID 66743611, compound → HCID 66744221, compound

Participants

Reaction Steps

A mixture of 2,2-dimethyl-6-(5-methyl-1H-pyrazol-4-yl)-1-(3-nitrobenzyl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (147 mg, 0.37 mmol), platinum(IV) oxide (15 mg) and ethanol (20 mL) was stirred at room temperature for 3 h under hydrogen atmosphere (1 atm). Then, the catalyst was removed by filtration. After removal of the solvent at reduced pressure, the residue was purified by column chromatography (Purif, silica gel, EtOAc to 90:10 EtOAc/MeOH), then crystallized from MeOH/EtOAc/hexane to give the title compound (52 mg, 38%) as a yellow solid:

Provenance & Evidence