Ethyl Acetate → HCID 19791668, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-4-methyl-1-(4-methylphenyl)pentane-1-one (13.5 g, 50 mmol) and potassium phthalimide (9.26 g, 50 mmol) were thoroughly mixed and heated at 160° C. for 2 hours. After being cooled, the reaction mixture was added with ethyl acetate (100 ml) and with water (50 ml). The resulting organic layer was separated and washed with brine. The organic solution was then dried over sodium sulfate and evaporated under reduced pressure. The residue was crystallized by treatment with hexane and the resulting crystals were recrystallized from hexane to obtain 12.2 g of the intended compound as white crystals (yield: 73%).

Provenance & Evidence