Methanol → Methyl 3-amino-5-bromothiophene-2-carboxylate

Participants

Reaction Steps

A mixture of methyl 5-bromo-3-[(trifluoroacetyl)amino]thiophene-2-carboxylate (8.15 g, 24.5 mmol), potassium carbonate (4.15 g, 30 mmol), MeOH (200 mL) and water (100 mL) was stirred at room temperature for 2 h. The mixture was concentrated to about a half volume and poured into saturated aqueous NaHCO3 (300 mL). Extraction with EtOAc (300 mL), washing with brine, drying over MgSO4, filtration and concentration under reduced pressure gave the title compound as a yellow solid (5.67 g, 98%):

Provenance & Evidence