HCID 86741310, compound → HCID 19791682, compound

2-Hydroxyimino-1-(4-methoxyphenyl)-4-methyl-pentane-1-one (8.72 g; 37.1 mmol) was dissolved in acetic acid (88 ml). The solution was added with 5% palladium-charcoal (0.87 g) and the reactant was catalytically hydrogenated at normal pressure and at 80° C. until hydrogen was absorbed in a molar amount of three times that of the reactant. After removal of the catalyst by filtration, the acetic acid was removed under reduced pressure. The residue was dissolved in 1N hydrochloric acid (80 ml). The solution was washed twice with ether (30 ml) and the aqueous layer was basified with a 20% aqueous solution of sodium hydroxide. The aqueous layer thus treated was extracted three times with chloroform and the extracts were combined together and then washed once with brine. The resulting extract was dried over sodium sulfate and the solvent was removed by distillation under reduced pressure to give light-yellowish crystals (6.80 g). The crystals were recrystallized from benzene and hexane to obtain 5.24 g of the intended compound as white crystals (yield: 63%).

1. customwas absorbed in a molar amount of three times that of the reactant
2. customAfter removal of the catalyst
3. filtrationby filtration
4. customthe acetic acid was removed under reduced pressure
5. dissolutionThe residue was dissolved in 1N hydrochloric acid (80 ml)
6. washThe solution was washed twice with ether (30 ml)
7. additionThe aqueous layer thus treated
8. extractionwas extracted three times with chloroform
9. washwashed once with brine
10. extractionThe resulting extract
11. dry with materialwas dried over sodium sulfate
12. customthe solvent was removed by distillation under reduced pressure

ORD record

ord-47db29531a244088b815ba54d119076c

Source dataset

uspto-grants-1987_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04644063