HCID 68074178, compound → HCID 66744038, compound

Participants

Reaction Steps

A mixture of benzyl [6′-(5-methyl-1H-pyrazol-4-yl)-4′-oxo-3′,4′-dihydro-1′H-spiro[cyclohexane-1,2′-thieno[3,2-d]pyrimidin]-4-yl]carbamate (the isomer ratio was 1:1, 78 mg, 0.173 mmol), 10% Pd/C (20 mg, 50% wet) and MeOH (5 mL) was stirred for 1 h at room temperature under H2 atmosphere. Then, 20% palladium hydroxide on carbon (200 mg, 50% wet) was added. After 1 h, the mixture was filtered through a pad of celite, and the celite was washed with MeOH well. The filtrate was concentrated under reduced pressure, and the residue was triturated with MeOH/EtOAc. The precipitate was collected by filtration to afford the title compound (35.3 mg, 64%, a mixture of 1:1 cis/trans isomers) as a white solid:

Provenance & Evidence