1-Ethynyl-4-(trifluoromethyl)benzene → 4-Methyl-2-[4'-trifluoromethyl-5-(4-trifluoromethyl-phenylethynyl)-biphenyl-3-yl]-pentanoic acid

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The title compound was prepared from a Sonogashira coupling of 4-methyl-2-(5-trifluoromethyl-biphenyl-3-yl)pentanoic acid (intermediate compound 1g) with 1-ethynyl-4-trifluoromethyl-benzene under the conditions described in Example 10; 1H NMR (400 MHz, MeOD) δ ppm 0.86 (dd, J=6.60, 1.96 Hz, 6 H), 1.44 (dt, J=13.45, 6.72 Hz, 1 H), 1.62 (ddd, J=13.82, 7.09, 6.97 Hz, 1 H), 1.87-1.97 (m, 1 H), 3.70 (t, J=7.83 Hz, 1 H), 7.49 (d, J=1.47 Hz, 1 H), 7.57-7.73 (m, 9 H).

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