Ethyl 3-chloro-3-oxopropionate → HCID 54729996, compound

Participants

Reaction Steps

This compound was prepared from ethyl 3-amino-5-benzylpyridine-2-carboxylate and ethyl 3-chloro-3-oxopropionate employing methods similar to those described in Example 1, Steps 9-10. The product was obtained as a white solid: 1H NMR (d6-DMSO) δ 10.72 (1H, br s), 8.24 (1H, br s), 7.36-7.23 (6H, m), 4.14 (2H, q, J=7 Hz), 4.06 (2H, s), 1.22 (3H, t, J=7 Hz); ES+ MS: 325 (M+H+, 75), 347 (M+Na+, 26); Anal. Calcd for C18H16N2O4: C, 53.61; H, 3.99; N, 6.94. Found: C, 53.40; H, 3.92; N, 6.92.

Provenance & Evidence