Hydrochloric Acid → HCID 58882900, compound

Participants

Reaction Steps

A solution of 1M NaOEt in EtOH (2.5 mL, 2.5 mmol) was added dropwise to a solution of ethyl 5-benzyl-3-{(3-ethoxy-3-oxopropanoyl)[4-(methylsulfonyl)benzyl]-amino}-pyridine-2-carboxylate (690 mg, 1.26 mmol) in EtOH (6 mL). The mixture was stirred at rt for 30 min, neutralized with 1M HCl (2.5 mL) and the resulting precipitate was collected by filtration washing with 1:1 water/EtOH. This procedure afforded the product as an off-white solid: 1H NMR (CDCl3) δ 14.07 (1H, br s), 8.56 (1H, s), 7.79 (2H, d, J=8 Hz), 7.30 (3H, m), 7.19 (2H, d, J=8 Hz), 7.02 (3H, m), 5.40 (2H, br s), 4.53 (2H, q, J=7 Hz), 4.04 (2H, s), 3.01 (3H, s), 1.48 (3H, s); HRMS calcd for C26H24N2O6S+H+: 493.1433. Found: 493.1422.

Provenance & Evidence