4-Pyridinemethanamine → HCID 58882895, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 7-benzyl-4-hydroxy-1-[4-(methylsulfonyl)benzyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (40 mg, 0.080 mmol) and 4-(aminomethyl)pyridine (122 μL, 1.2 mmol) in EtOH (1 mL) was heated at 120° C. in a sealed tube in a microwave for 30 min. The reaction mixture was concentrated at reduced pressure, reconstituted in CH2Cl2 and washed with a mixture of 1N HCl and brine. Drying and evaporation of the organic phase gave the product as a pale green solid: 1H NMR (CDCl3) δ 10.81 (1H, br t, J=6 Hz), 8.69 (2H, d, J=7 Hz), 8.65 (1H, d, J=1 Hz), 7.83 (2H, d, J=8 Hz), 7.76 (2H, d, J=6 Hz), 7.31 (3H, m), 7.19 (2H, d, J=8 Hz), 7.11 (1H, s), 7.03 (2H, m), 5.43 (2H, br s), 4.86 (2H, d, J=6 Hz), 4.08 (2H, s), 3.03 (3H, s); HRMS calcd for C30H26N4O5S+H+: 555.1702. Found: 555.1699.

Provenance & Evidence