1-Aminohomopiperidine → HCID 54681850, compound

HRID 2364166Notes

Reaction equation

HRID 2364166 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:25])=[C:14]([C:20]([O:22]CC)=O)[C:15](=[O:19])[NH:16]3)=[N:11][CH:10]=2)=[CH:4][CH:3]=1.[N:26]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:18]=[C:17]3[C:12]([C:13]([OH:25])=[C:14]([C:20]([NH:33][N:26]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[O:22])[C:15](=[O:19])[NH:16]3)=[N:11][CH:10]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 221981-AminohomopiperidineHCID 54729997Ethyl 7-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

Product 1

HCID 54681850HCID 54681850, compound

Procedure

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and hexahydro-1-H-azepin-1-amine employing methods similar to those described in Example 2 and was obtained as a white solid: 1H NMR (d6-DMSO) δ 12.90 (1H, br), 11.80 (1H, br), 10.13 (1H, br), 8.15 (1H, br s), 7.23 (3H, m), 7.11 (2H, t, J=8.8 Hz), 3.97 (2H, s), 2.94 (4H, m), 1.59 (8H, m); ES+ MS: 411 (M+H+, 100).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-1438730cd4c64f20820021221486f118
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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