HCID 13704347, compound → HCID 13704345, compound

HRID 236418Notes

Reaction equation

HRID 236418 reaction equation
[NH2:1][C:2]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]2[O:6][C:7]([CH3:18])([CH3:17])[C@@H:8]([OH:16])[C@H:9]([N:10]3[CH2:14][CH2:13][CH2:12][C:11]3=[O:15])[C:4]=2[CH:3]=1.[N+](C1C(NC(=O)C)=C[C:30]2[O:31]C(C)(C)[C@@H](O)[C@H](N3CCCC3=O)[C:29]=2C=1)([O-])=O.[N+](C1C(N)=CC2OC(C)(C)[C@@H](O)[C@H](N3CCCC3=O)C=2C=1)([O-])=O.C(C1C(N)=CC2OC(C)(C)[C@@H](O)[C@H](N3CCCC3=O)C=2C=1)#N>>[C:30]([NH:1][C:2]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][C:5]2[O:6][C:7]([CH3:17])([CH3:18])[C@@H:8]([OH:16])[C@H:9]([N:10]3[CH2:14][CH2:13][CH2:12][C:11]3=[O:15])[C:4]=2[CH:3]=1)(=[O:31])[CH3:29]

Participants

5

Reactant 4

HCID 13704347HCID 13704347, compoundHCID 13704349HCID 13704349, compoundHCID 13704351HCID 13704351, compoundHCID 70429232HCID 70429232, compound

Product 1

HCID 13704345HCID 13704345, compound

Procedure

6-amino-7-nitro-3,4-dihydro-trans-4-(2-ketopyrrolidinyl)2,2-dimethyl-2H-benzo[b]pyran-3-ol or a pharmaceutically acceptable salt thereof; 6-nitro-7-acetamido-3,4-dihydro-trans-4-(2-ketopyrrolidinyl)-2,2-dimethyl-2H-benzo[b]pyran-3-ol; 6-nitro-7-amino-3,4-dihydro-trans-4-(2-ketopyrrolidinyl)-2,2-dimethyl-2H-benzo[b]pyran-3-ol or a pharmaceutically salt thereof; or 6-cyano-7-amino-3,4-dihydro-trans-4-(2-ketopyrrolidinyl)-2,2-dimethyl-2H-benzo[b]pyran-3-ol or a pharmaceutically acceptable salt thereof.

Sources & evidence

ORD record
ord-e9306b49a37147e7a673a19defdea576
Source dataset
uspto-grants-1987_02
Patent number
US04644070

Reaction notes

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