2-Aminopropanol → HCID 58882928, compound

Participants

Reaction Steps

This compound was prepared from 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-{methyl[2-(methyloxy)ethyl]amino}-2-oxoethyl)-2-oxo-1,2-dihydro-1,5naphthyridine-3-carboxylate and (±)-2-amino-1-propanol employing methods similar to those described in Example 5, Step 4 and was obtained as an off-white solid: 1H NMR (CDCl3) mixture of rotamers δ 10.21 and 10.19 (1H, br d), 8.55 and 8.49 (1H, s), 7.33 and 7.10 (1H, s), 7.12-6.97 (4H, m), 5.21 and 4.97 (2H, m), 4.27 (1H, m), 4.09 (2H, s), 3.80-3.50 (6H, m), 3.34 and 3.32 (3H, s), 3.17 and 2.97 (3H, s), 1.30 and 1.29 (3H, d, J=7 Hz); HRMS calcd for C25H29FN4O6+H+: 501.2149. Found: 501.2160.

Provenance & Evidence