D(-)-Leucinol → HCID 69482476, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(2-oxohexahydro-1H-azepin-1-yl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (2R)-2-amino-4-methyl-1-pentanol using methods similar to Example 563 to provide a pink solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 0.90 (dd, J=6.42, 1.79 Hz, 6 H), 1.39-1.49 (m, 2 H), 1.55 (d, J=5.48 Hz, 4 H), 1.59-1.75 (m, 5 H), 2.35-2.45 (m, 2 H), 3.37 (d, J=8.00 Hz, 2 H), 3.40 (s, 2 H), 3.48 (s, 2 H), 4.04-4.13 (m, 1 H), 4.19 (s, 4 H), 4.93 (s, 1 H), 7.11-7.18 (m, 2 H), 7.41 (dd, J=8.74, 5.58 Hz, 2 H), 7.99 (s, 1 H), 8.56 (d, J=1.47 Hz, 1 H), 10.31 (d, J=8.63 Hz, 1 H), 17.26 (s, 1 H); ES+ MS: 567 (M+H+).

Provenance & Evidence