Sodium Hydroxide → sodium 1-ethyl-7-[(4-fluorophenyl)methyl]-3-({[(1S)-2-hydroxy-1-methylethyl]amino}carbonyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-4-olate

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Reaction Steps

In manner similar to that described in example 474, from 1-ethyl-7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[(1S)-2-hydroxy-1-methylethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (757 mg, 1.90 mmol described in example 576) and 1 N sodium hydroxide (1.84 mL) was prepared sodium 1-ethyl-7-[(4-fluorophenyl)methyl]-3-({[(1S)-2-hydroxy-1-methylethyl]amino}carbonyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-4-olate (626 mg, 78% yield) as a white solid. 1H NMR (DMSO-d6) δ 10.43 (d, J=7.2 Hz, 1 H), 8.14 (s, 1 H), 7.59 (s, 1 H), 7.33-7.29 (m, 2 H), 7.12-7.07 (m, 2 H), 4.83 (m, 1 H), 4.10-4.03 (m, 4 H), 3.91 (m, 1 H), 3.40 (m, 1 H), 3.25-3.22 (m, 2 H), 1.07-1.03 (m, 5 H); MS m/z 422 (M+23).

Provenance & Evidence