HCID 69482820, compound → HCID 69483060, compound

Participants

Reaction Steps

A mixture of methyl 5-[(3,4-difluorophenyl)methyl]-3-nitro-2-pyridinecarboxylate (1.67 g, 5.42 mmol), 10% Pd-C (1.67 g) and MeOH (170 ml) was reduced under hydrogen for 2 h. The product was filtered through Celite, concentrated in vacuo and purified by chromatography on silica gel, eluting with 50-75% EtOAc/hexanes. The product was triturated with EtOAc to afford an off-white solid collected by filtration. 1H NMR (d6-DMSO) δ 7.77 (1H, s), 7.39-7.30 (2H, m), 7.08-7.05 (1H, m), 6.92 (1H, s), 6.62 (2H, s), 3.88 (2H, s), 3.76 (3H, s); HRMS calcd for C14H12F2N2O2+H+: 279.0945. Found 279.0938.

Provenance & Evidence