Ethanolamine → HCID 69482163, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-oxo-2-(1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine employing methods similar to those those described in Example 9 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (CDCl3) δ 10.32 (1H, m), 8.56 (1H, s), 7.16 (2H, dd, J=9, 6 Hz), 7.03 (2H, t, J=9 Hz), 6.97 (1H, s), 4.93 (2H, s), 4.11 (2H, s), 3.83 (2H, t, J=5 Hz), 3.62 (2H, q, J=5 Hz), 3.50 (2H, t, J=6 Hz), 3.44 (2H, t, J=5 Hz), 1.69-1.58 (6H, m); HRMS calcd for C25H27FN4O5+H+: 483.2044. Found: 483.2060.

Provenance & Evidence