2-Methoxyethylamine → HCID 69480760, compound

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Reaction Steps

A solution of 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (20 mg, 0.05 mmol) in 2-methoxyethylamine (1 mL) was heated with a microwave at 140° C. for 20 minutes. The solvent was removed in vacuo and the residue was purified by reverse phase preparative HPLC to give the title compound (17 mg, 79%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.35 (br, 1 H), 8.54 (s, 1 H), 7.25 (s, 1 H), 7.15 (dd, J=8.5, 5.4 Hz, 2 H), 7.03 (t, J=8.5 Hz, 2 H), 4.12 (s, 2 H), 3.97 (br, 2 H), 3.63 (m, 2 H), 3.57 (m, 2 H), 3.39 (s, 3 H), 1.95 (m, 1 H), 0.87 (d, J=6.8 Hz, 6 H); HRMS m/z calcd for C23H27N3O4 (M+H)+ 428.1986, found 428.1977.

Provenance & Evidence