2-Aminopropanol → HCID 69482083, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-oxo-2-(1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (±)-2-amino-1-propanol employing methods similar to those those described in Example 9 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (CDCl3) δ 14.1 (1H, br), 10.16 (1H, d, J=7 Hz), 8.56 (1H, s), 7.16 (2H, dd, J=8.5, 6 Hz), 7.03 (2H, t, J=8.5 Hz), 6.93 (1H, s), 4.96 (1H, d, J=7 Hz), 4.89 (1H, d, J=7 Hz), 4.27 (1H, m), 4.11 (2H, s), 3.74 (1H, m), 3.66 (1H, m), 3.50 (2H, t, J=5.5 Hz), 3.43 (2H, t, J=5.5 Hz), 2.23 (1H, m), 1.69 (2H, m), 1.52 (4H, m), 1.29 (3H, d, J=7 Hz); HRMS calcd for C26H29FN4O5+H+: 497.2200. Found: 497.2186.

Provenance & Evidence