Ethoxyethylamine → HCID 69480851, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[2-(4-morpholinyl)-2-oxoethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-ethoxyethylamine employing methods similar to those those described in Example 9 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (CDCl3) δ 10.14 (1H, m), 8.55 (1H, s), 7.15 (2H, dd, J=8.5, 5.5 Hz), 7.04 (3H, m), 4.94 (2H, s), 4.11 (2H, s), 3.73-3.52 (14H, m), 1.22 (3H, t, J=7 Hz); HRMS calcd for C26H29FN4O6+H+: 513.2149. Found: 513.2134.

Provenance & Evidence