N-(3-Aminopropyl)morpholine → HCID 69482833, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(1-pyrrolidinylsulfonyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-aminopropyl morpholine employing methods similar to those described in Example 202 and was obtained as a white solid: 1H NMR (400 MHz, CDCl3) δ 10.22 (t, J=5.3 Hz, 1 H), 8.57 (s, 1 H), 7.76 (s, 1 H), 7.22 (dd, J=8.5, 5.5 Hz, 2 H), 7.02 (t, J=8.6 Hz, 2 H), 4.39 (t, J=8.0 Hz, 2 H), 4.13 (s, 2 H), 3.84-3.82 (m, 4 H), 3.53 (q, J=6.6 Hz, 2 H), 3.38-3.34 (m, 4 H), 3.06 (t, J=6.5 Hz, 2 H), 2.71-2.62 (m, 6 H), 2.17 (m, 2 H), 1.98-1.93 (m, 6 H); HRMS C30H38FN5O6S (M+H)+ calcd 616.2527, found 616.2609.

Provenance & Evidence