Methoxyisopropylamine → HCID 69480953, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[3-(1-pyrrolidinylsulfonyl)propyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-methoxy isopropylamine employing methods similar to those described in Example 202 and was obtained as a white solid: 1H NMR (300 MHz, CDCl3) δ 10.17 (d, J=8.6 Hz, 1 H), 8.56 (s, 1 H), 7.75 (s, 1 H), 7.22 (m, 2 H), 7.02 (t, J=8.7 Hz, 2 H), 4.43-4.33 (m, 3 H), 4.13 (s, 2 H), 3.48 (d, J=4.7 Hz, 2 H), 3.41 (s, 3 H), 3.38-3.33 (n, 4 H), 3.05 (t, J=6.5 Hz, 2 H), 2.17 (m, 2 H), 1.97-1.92 (m, 4 H), 1.31 (d, J=7.0 Hz, 3 H); HRMS C27H33FN4O6S (M+H)+ calcd 561.2105, found 561.2189.

Provenance & Evidence