1-Propanol, 3-amino-2,2-dimethyl- → HCID 69480222, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-amino-2,2-dimethyl-1-propanol employing methods similar to those those described in Example 9 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (CDCl3) δ 14.4 (1H, br), 10.32 (1H, m), 8.56 (1H, s), 7.15 (2H, dd, J=8.6, 5.5 Hz), 7.02 (3H, m), 4.88 (2H, s), 4.12 (2H, s), 3.49 (2H, t, J=7 Hz), 3.46 (2H, t, J=7 Hz), 3.33 (1H, t, J=7 Hz), 3.30 (2H, d, J=7 Hz), 3.24 (2H, d, J=7 Hz), 2.05 (2H, m, J=7 Hz), 1.90 (2H, m, J=7 Hz), 0.94 (6H, s); HRMS calcd for C27H31FN4O5+H+: 511.2357. Found: 511.2341.

Provenance & Evidence