N-(3-Aminopropyl)morpholine → HCID 69482546, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(2,4-difluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 4-(3-aminopropyl)morpholine employing methods similar to those described in Example 2 and was obtained as a white solid: 1H NMR (d6-DMSO) tautomers are observed δ 11.75 (1H, br s), 10.7 (1H, br s), 10.20 (1H, br s), 8.17 (0.45H, s), 8.15 (0.55H, s), 7.45-7.21 (3H, m), 7.10-7.04 (1H, m), 4.02 (2H, s), 3.56-3.51 (4H, m), 3.31-3.24 (2H, m), 2.48-2.32 (6H, m), 1.65-1.61 (2H, m); HRMS calcd for C23H24F2N4O4+H+: 459.1844. Found 459.1856.

Provenance & Evidence