2-Methoxyethylamine → HCID 69481099, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-[2-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-methoxyethylamine employing methods similar to those described in Example 202 and was obtained as a white solid: 1H NMR (400 MHz, CDCl3) δ 10.23 (s, 1 H), 8.55 (s, 1 H), 7.85 (s, 1 H), 7.23 (m, 2 H), 6.99 (t, J=8.7 Hz, 2 H), 4.37 (t, J=7.2 Hz, 2 H), 4.10 (s, 2 H), 3.64 (q, J=5.2 Hz, 2 H), 3.58 (m, 2 H), 3.43-3.35 (m, 4 H), 3.41 (s, 3 H), 2.95 (t, J=6.1 Hz, 2 H), 2.17 (m, 2 H), 1.57 (m, 2 H); MS m/z 533 (M+H)+.

Provenance & Evidence