Diglycolamine → HCID 69480204, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-[2-(dimethylamino)-2-oxoethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-[(2-aminoethyl)oxy]ethanol employing methods similar to those described in Example 245 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (d6-DMSO) δ 10.22 (1H, br t), 8.51 (1H, s), 7.74 (1H, s), 7.31 (2H, dd, J=8.4, 5.7 Hz), 7.12 (2H, t, J˜9 Hz), 5.12 (2H, s), 4.59 (1H, t, J=5 Hz), 4.11 (2H, s), 3.57-3.38 (8H, m), 3.12 (3H, s), 2.82 (3H, s); HRMS calcd for C24H27FN4O6+H: 487.1993. Found: 487.2007.

Provenance & Evidence