2-Methoxyethylamine → HCID 69480473, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[3-(methylsulfonyl)propyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-methoxyethylamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.22 (s, 1 H), 8.57 (s, 1 H), 7.67 (s, 1 H), 7.21 (dd, J=8.6, 5.5 Hz, 2 H), 7.01 (t, J=8.7 Hz, 2 H), 4.39 (t, J=7.8 Hz, 2 H), 4.12 (s, 2 H), 3.65 (m, 2 H), 3.59 (m, 2 H), 3.41 (s, 3 H), 3.14 (t, J=7.0 Hz, 2 H), 2.95 (s, 3 H), 2.21 (m, 2 H); HRMS C23H26FN3O6S (M+H)+ calcd 492.1526, found 492.1603.

Provenance & Evidence