Ethanolamine → HCID 69482040, compound

Participants

Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[3-(methylsulfonyl)propyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.33 (t, J=4.9 Hz, 1 H), 8.56 (s, 1 H), 7.67 (s, 1 H), 7.22 (dd, J=8.4, 5.4 Hz, 2 H), 7.01 (t, J=8.6 Hz, 2 H), 4.37 (t, J=7.8 Hz, 2 H), 4.12 (s, 2 H), 3.86 (t, J=5.2 Hz, 2 H), 3.63 (m, 2 H), 3.14 (t, J=6.8 Hz, 2 H), 2.95 (s, 3 H), 2.18 (m, 2 H); HRMS C22H24FN3O6S (M+H)+ calcd 478.1370, found 478.1440.

Provenance & Evidence