1-(3-Aminopropyl)-2-pyrrolidinone → HCID 69482016, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[3-(methylsulfonyl)propyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(3-aminopropyl)-2-pyrrolidinone employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.23 (t, J=5.5 Hz, 1 H), 8.55 (s, 1 H), 7.65 (s, 1 H), 7.20 (dd, J=8.5, 5.4 Hz, 2 H), 7.00 (t, J=8.8 Hz, 2 H), 4.39 (t, J=7.7 Hz, 2 H), 4.11 (s, 2 H), 3.46-3.35 (m, 6 H), 3.13 (t, J=7.1 Hz, 2 H), 2.94 (s, 3 H), 2.39 (t, J=8.2 Hz, 2 H), 2.19 (m, 2 H), 2.03 (m, 2 H), 1.85 (m, 2 H); HRMS C27H31FN4O6S (M+H)+ calcd 559.1948, found 559.2055.

Provenance & Evidence