1-Amino-2-propanol → HCID 69482841, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-[3-(methylsulfonyl)propyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-amino-2-propanol employing methods similar to those described in Example 202 and was obtained as a pale yellow solid. 1H NMR (400 MHz, CDCl3) δ 10.33 (t, J=5.1 Hz, 1 H), 8.56 (s, 1 H), 7.67 (s, 1 H), 7.21 (dd, J=8.2, 5.4 Hz, 2 H), 7.01 (t, J=8.5 Hz, 2 H), 4.37 (t, J=7.7 Hz, 2 H), 4.12 (s, 2 H), 4.08 (m, 2 H), 3.62 (m, 1 H), 3.35 (m, 1 H), 3.14 (t, J=6.7 Hz, 2 H), 2.95 (s, 3 H), 2.19 (m, 2 H), 1.27 (d, J=6.4 Hz, 3 H); HRMS C23H26FN3O6S (M+H)+ calcd 492.1526, found 492.1623.

Provenance & Evidence