N-(2-aminoethyl)acetamide → HCID 69480435, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (20 mg, 0.056 mmol) described in example 92 and N-(2-aminoethyl)acetamide (74 mg, 0.730 mmol), was prepared N-[2-(acetylamino)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (9 mg, 39% yield) as a white solid after purification by reverse phase HPLC. 1H NMR (CDCl3) δ 10.39 (br s, 1 H), 8.56 (s, 1 H), 7.39 (s, 1 H), 7.17-7.15 (m, 2 H), 7.04-6.94 (m, 2 H), 6.09 (br s, 1 H), 4.13 (s, 2 H), 3.61-3.58 (m, 2 H), 3.57 (s, 3 H), 3.51-3.48 (m, 2 H), 1.98 (s, 3 H); MS m/z 413 (M+1).

Provenance & Evidence