Ethanolamine → HCID 69480293, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-{2-[(methylsulfonyl)amino]ethyl}-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 10.38 (t, J=5.2 Hz, 1 H), 8.55 (s, 1 H), 8.10 (s, 1 H), 7.40 (dd, J=8.2, 5.7 Hz, 2 H), 7.27 (t, J=6.1 Hz, 1 H), 7.13 (t, J=8.8 Hz, 2 H), 4.95 (t, J=5.0 Hz, 1 H), 4.34 (t, J=6.3 Hz, 2 H), 4.14 (s, 2 H), 3.57 (m, 2 H), 3.45 (m, 2 H), 3.24 (m, 2 H), 2.89 (s, 3 H); HRMS C21H23FN4O6S (M+H)+ calcd 479.1322, found 479.1400.

Provenance & Evidence