3-Amino-1-propanol → HCID 69480408, compound

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Reaction Steps

This compound was prepared from methyl 7-{[4-fluoro-2-(trifluoromethyl)phenyl]methyl}-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 3-amino-1-propanol employing methods similar to those described in Example 245 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a white solid: 1H NMR (d6-DMSO) δ 11.74 (1H, br), 10.26 (1H, m), 8.49 (1H, s), 7.70 (1H, d, J=9 Hz), 7.56 (2H, m), 7.32 (1H, s), 4.58 (1H, t, J=5 Hz), 4.32 (2H, s), 3.51-3.40 (4H, m), 1.70 (2H, m, J=6 Hz); HRMS calcd for C20H17F4N3O4+H+: 440.1233. Found: 440.1241.

Provenance & Evidence