1-(3-Aminopropyl)-2-pyrrolidinone → HCID 69482446, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-{[4-(methylsulfonyl)phenyl]methyl}-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1-(3-aminopropyl)-2-pyrrolidinone employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.25 (t, J=5.3 Hz, 1 H), 8.57 (s, 1 H), 7.84 (d, J=8.2 Hz, 2 H), 7.20 (d, J=8.1 Hz, 2 H), 7.02-6.97 (m, 5 H), 5.45 (br, 2 H), 4.02 (s, 2 H), 3.50-3.38 (m, 6 H), 3.03 (s, 3 H), 2.39 (t, J=7.9 Hz, 2 H), 2.04 (m, 2 H), 1.88 (m, 2 H); HRMS C31H31FN4O6S (M+H)+ calcd 607.1948, found 607.2043.

Provenance & Evidence