2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 69482202, compound

Participants

Reaction Steps

In a similar manner to that described in example 316 step 1, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (50 mg, 0.146 mmol), lithium (bis-trimethylsilyl)amide (49 mg, 0.292 mmol), and 2,2,2-trifluoroethyl trifluoromethanesulfonate (0.2 mL, 0.876 mmol) was prepared ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydro-1,5-naphthyridine-3-carboxylate (58 mg, 95% yield) as a yellow oil. 1H NMR (CDCl3) δ 8.54 (s, 1 H), 7.37 (s, 1 H), 7.16-7.12 (m, 2 H), 7.04-6.97 (m, 2 H), 4.83 (m, 2 H), 4.49 (m, 2 H), 4.13 (s, 2 H), 1.46 (m, 3 H); MS m/z 425 M+1).

Provenance & Evidence