1-Aminocyclopentanemethanol → HCID 69480289, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (18 mg, 0.050 mmol) described in example 92 and (1-aminocyclopentyl)methanol (76 mg, 0.66 mmol) was prepared 7-[(4-fluorophenyl)methyl]-4-hydroxy-N-[1-(hydroxymethyl)cyclopentyl]-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide(10 mg, 48% yield) as a white solid after purification by reverse phase HPLC. 1H NMR (CDCl3) δ 10.56 (br s, 1H), 8.55 (s, 1 H), 7.37 (s, 1 H), 7.17-7.14 (m, 2 H), 7.04-6.99 (m, 2 H), 4.12 (s, 2 H), 3.78 (s, 2 H), 3.56 (s, 3 H), 1.98-1.68 (m, 8 H); MS m/z 424 (M−1).

Provenance & Evidence