Triethylamine → HCID 69480938, compound

Participants

Reaction Steps

In a similar manner to that described in example 196, from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate (30 mg, 0.084 mmol) described in example 92, triethylamine (0.05 mL, 0.364 mmol) and [2-(methylsulfonyl)ethyl]amine hydrochloride (174 mg, 1.08 mmol) was prepared 7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-N-[2-(methylsulfonyl)ethyl]-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide (11 mg, 22% yield) as a white solid after purification by reverse phase HPLC. 1H NMR (CDCl3) δ 10.61 (br s, 1 H), 8.56 (s, 1 H), 7.39 (s, 1 H), 7.16-7.12 (m, 2 H), 7.04-6.99 (m, 2 H), 4.13 (s, 2 H), 3.95 (m, 2 H), 3.57 (s, 3 H), 3.37 (m, 2 H), 2.98 (s, 3 H); MS m/z 434 (M+1).

Provenance & Evidence