Ethyl 7-[(4-Fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate → HCID 69482492, compound

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Reaction Steps

This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and R-(−)-2-amino-1-propanol employing methods similar to those described in Example 2 and using N,N-dimethylformamide as the reaction solvent. The product was obtained as an off-white solid: 1H NMR (d6-DMSO) tautomers are observed δ 11.72 (1H, br s), 10.70 (1H, br s), 10.04 (1H, br s), 8.17 (0.23H, s), 8.14 (0.77H, s), 7.34-7.22 (3H, m), 7.14-7.08 (2H, m), 4.79-4.77 (1H, m), 3.98 (2H, s), 3.97-3.92 (1H, m), 3.29-3.21 (1H, m), 1.13 (1.65H, d, J=6.6 Hz),1.08 (1.35H, d, J=6.6 Hz); HRMS calcd for C19H18FN3O4+H+: 372.1354. Found 372.1361.

Provenance & Evidence