Ethyl 3-amino-5-(4-fluorobenzyl)picolinate → HCID 69480935, compound

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Reaction Steps

This compound was prepared from ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate and (1,1-dioxido-2-isothiazolidinyl)acetaldehyde employing methods similar to those described in Example 265 and was obtained as a brownish oil. 1H NMR (400 MHz, CDCl3) δ 7.92 (s, 1 H), 7.89 (br, 1 H), 7.14 (dd, J=8.4, 5.4 Hz, 2 H), 6.98 (t, J=8.6 Hz, 2 H), 6.92 (s, 1 H), 4.41 (q, J=7.2 Hz, 2 H), 3.91 (s, 2 H), 3.41 (m, 2 H), 3.29-3.24 (m, 4 H), 3.13 (t, J=7.7 Hz, 2 H), 2.31 (m, 2 H), 1.41 (t, J=7.0 Hz, 3 H); MS m/z 422 (M+H)+.

Provenance & Evidence