Ethanolamine → HCID 69480326, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-[2-(1,1-dioxido-2-isothiazolidinyl)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and ethanolamine employing methods similar to those described in Example 202 and was obtained as an white solid. 1H NMR (400 MHz, CDCl3) δ 10.37 (t, J=5.3 Hz, 1 H), 8.59 (s, 1 H), 7.87 (s, 1 H), 7.24 (m, 2 H), 7.02 (t, J=8.6 Hz, 2 H), 4.42 (t, J=7.0 Hz, 2 H), 4.13 (s, 2 H), 3.87 (t, J=5.2 Hz, 2 H), 3.65 (m, 2 H), 3.36 (t, J=7.0 Hz, 2 H), 3.26 (t, J=6.5 Hz, 2 H), 3.08 (t, J=7.5 Hz, 2 H), 2.25 (m, 2 H); HRMS C23H25FN4O6S (M+H)+ calcd 505.1479, found 505.1558.

Provenance & Evidence