Ethoxyethylamine → HCID 69482456, compound

HRID 2364365Notes

Reaction equation

[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[N:20][CH:21]=[C:22]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH:23]=2)[C:18]([OH:33])=[C:17]([C:34](OCC)=[O:35])[C:16]1=[O:39].[CH2:40]([O:42][CH2:43][CH2:44][NH2:45])[CH3:41]>>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][CH2:14][N:15]1[C:24]2[C:19](=[N:20][CH:21]=[C:22]([CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)[CH:23]=2)[C:18]([OH:33])=[C:17]([C:34]([NH:45][CH2:44][CH2:43][O:42][CH2:40][CH3:41])=[O:35])[C:16]1=[O:39]

Participants

Reactant 2

HCID 66970Ethoxyethylamine

HCID 69482061HCID 69482061, compound

Product 1

HCID 69482456HCID 69482456, compound

Procedure

This compound was prepared from ethyl 1-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-(ethyloxy)ethanamine employing methods similar to those described in Example 370 and was obtained as a white solid: ES+ MS: 573 (M+H+).

Workup

customwas obtained as a white solid

Sources & evidence

ORD record: ord-8445fea2e85f4a63b0c40145a969d47d
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691991B2

Reaction notes

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