2-Methoxyethylamine → HCID 69483254, compound

Participants

Reaction Steps

This compound was prepared from ethyl 1-[2-(1, 1-dioxido-2-isothiazolidinyl)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 2-methoxyethylamine employing methods similar to those described in Example 202 and was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ 10.24 (s, 1 H), 8.58 (s, 1 H), 7.86 (s, 1 H), 7.24 (m, 2 H), 7.01 (t, J=8.6 Hz, 2 H), 4.42 (t, J=7.0 Hz, 2 H), 4.12 (s, 2 H), 3.65 (m, 2 H), 3.59 (m, 2 H), 3.42 (s, 3 H), 3.36 (t, J=6.9 Hz, 2 H), 3.26 (t, J=6.7 Hz, 2 H), 3.07 (t, J=7.5 Hz, 2 H), 2.24 (m, 2 H); HRMS C24H27FN4O6S (M+H)+ calcd 519.1635, found 519.1718.

Provenance & Evidence