1-Aminocyclopentanemethanol → HCID 69482705, compound

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Reaction Steps

This compound was prepared from ethyl 1-[2-(dimethylamino)-2-oxoethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate and (1-aminocyclopentyl)methanol employing methods similar to those described in Example 245 and was purified by reverse phase preparative HPLC (C-18 stationary phase; 10-100% CH3CN/water/0.1% formic acid mobile phase). The product was obtained as a cream-colored solid: 1H NMR (d6-DMSO) δ 10.32 (1H, s), 8.50 (1H, s), 7.74 (1H, s), 7.32 (2H, dd, J=8.5, 6 Hz), 7.12 (2H, t, J˜9 Hz), 5.12 (2H, s), 5.04 (1H, br), 4.11 (2H, s), 3.51 (2H, s), 3.12 (3H, s), 2.82 (3H, s), 1.91 (2H, m), 1.74 (4H, m), 1.56 (2H, m); HRMS calcd for C26H29FN4O5+H+: 497.2200. Found: 497.2200.

Provenance & Evidence