4-Morpholinecarbonyl chloride → HCID 69480285, compound

HRID 2364392Notes

Reaction equation

HRID 2364392 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)[CH:13]=2)[C:8]([OH:23])=[C:7]([C:24]([NH:26][CH2:27][CH2:28][O:29][CH2:30][CH3:31])=[O:25])[C:6]1=[O:32].[N:33]1([C:39](Cl)=[O:40])[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH2:30]([O:29][CH2:28][CH2:27][NH:26][C:24]([C:7]1[C:6](=[O:32])[N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:39]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)=[O:40])[C:14]2[C:9]([C:8]=1[OH:23])=[N:10][CH:11]=[C:12]([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1)[CH:13]=2)=[O:25])[CH3:31]

Participants

3

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 69481020HCID 69481020, compound

Product 1

HCID 69480285HCID 69480285, compound

Procedure

This compound was prepared from 1-(3-aminopropyl)-N-[2-(ethyloxy)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 4-morpholinecarbonyl chloride employing methods similar to those described in Step 2 of Example 373 and was obtained as a white solid: ES+ MS: 556 (M+H+).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-1032acfd069d43fbb9d0124433251a6e
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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