2-Thiophenecarbonyl chloride → HCID 69480392, compound

HRID 2364394Notes

Reaction equation

HRID 2364394 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)[CH:13]=2)[C:8]([OH:23])=[C:7]([C:24]([NH:26][CH2:27][CH2:28][O:29][CH2:30][CH3:31])=[O:25])[C:6]1=[O:32].[S:33]1[CH:37]=[CH:36][CH:35]=[C:34]1[C:38](Cl)=[O:39]>>[CH2:30]([O:29][CH2:28][CH2:27][NH:26][C:24]([C:7]1[C:6](=[O:32])[N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:38]([C:34]2[S:33][CH:37]=[CH:36][CH:35]=2)=[O:39])[C:14]2[C:9]([C:8]=1[OH:23])=[N:10][CH:11]=[C:12]([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1)[CH:13]=2)=[O:25])[CH3:31]

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 69481020HCID 69481020, compound

Product 1

HCID 69480392HCID 69480392, compound

Procedure

This compound was prepared from 1-(3-aminopropyl)-N-[2-(ethyloxy)ethyl]-7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxamide and 2-thiophenecarbonyl chloride employing methods similar to those described in Example 400 and was obtained as a white solid: ES+ MS: 553 (M+H+).

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-c02a6d804ed249e98f0fc8181cdd432f
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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